If a trade goes up after you enter, you can take 25-50% of the funds out at TP1, 25% more on TP2, 25% more on TP3.
For anyone who wants to aggressively secure profits, you can move that SL from entry to TP1 after TP2 hits and so on. You get the point. But the risk of doing this is even one wick up or down might close your position, so take a call based on your risk appetite.
Once trade hits TP1 please always make your Stop loss as Trailing Stop Loss which means move your SL to your entry after TP1 hit.
At any point in an active trade, if you don't feel comfortable with a position, feel free to either close a partial % of the position or close the entire trade at your own will. The caller cannot be responsible for your emotions and feelings, you will have to manage that yourself.
Your risk/reward ratio should ideally be minimum 1:3+ meaning for every $1 you risk, you have the potential of earning $3